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KMID : 0367419740150060011
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Journal of Korean Pediatric Society
1974 Volume.15 No. 6 p.11 ~ p.19
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STUDY ON THE ANTAGONIST OF ADH
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Abstract
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Since 1962, the Author and associates studid on the rabbit brain systematically and demonstrated that the 3 areas in the cortex, 6 areas in the thalamus and hypothalamus and 6 areas in the midbrain chowed osmoreceptic function by the osmotic stimulation, however the mechanisms remain unknown.
The urine amount of the rabbits stimulated with hypertonic solution directly in these areas decreased promptly and markedly. And these phenomenon might be due to the release of ADH from the hypothalamus and neutrohypophysis.
However it is hardly to think that the prompt and marked diuresis following the injection of H(_2)O in the above areas have resulted from the inhibition of release of ADH and or prompt deplwtion of ADH in the circulation. Therefore I began to wonder if some another factor, possibly due to an unidentified hormone such as diuretic hormone must be involved.
The present study was designed to examine the question of whether or not there is a diuretic humoral substance involved in the regulation of urine excretion. Korean white male rabbits(Lepus cuniculus Linne´ Var. domistics Gmelin) weighing exactly 1.8 kg were used for this work.
They were well htdrated orally by gaveging with 100 cc of 2% sodium chloride solution three times at one hour interval to maintain positive water balance throught each study.
Osmotic stimulation was applied with distilled water in amount of 0.05 ml each injected into the anterior hypothalamus bilaterally using stereotaxic apparatus.
Urine was collected through a indwelling catheter while the rabbit was placed on the holder.
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